Muchas gracias por responder....
 
El ejemplo que me ofreces Carlangueitor no me sirve ya que es para trabajar neo4j embebido y lo requiero como servidor remoto. 
Creo que mi error se encuentra sobre la configuracion del setings.py de Django.  
Este el mi archivo setings.py.... espero les aclare un poco... 
# Django settings for neo_prueba2 project. 
DEBUG = True
TEMPLATE_DEBUG = DEBUG 
ADMINS = (
    # ('Your Name', '
[email protected]'),
) 
MANAGERS = ADMINS
DATABASES = {
    'default': {
        'ENGINE': 'django.db.backends.sqlite3', # Add 'postgresql_psycopg2', 'mysql', 'sqlite3' or 'oracle'.
        'NAME': 'C:\\Users\\Miguel\\My Documents\\Aptana Studio 3 Workspace\\neo_prueba2\\sqlite.db',                      # Or path to database file if using sqlite3.
        'USER': '',                      # Not used with sqlite3.
        'PASSWORD': '',                  # Not used with sqlite3.
        'HOST': '',                      # Set to empty string for localhost. Not used with sqlite3.
        'PORT': '',                      # Set to empty string for default. Not used with sqlite3.
    }
} 
NEO4J_DATABASES = {
    'default' : {
        'HOST':'localhost',
        'PORT':7474,
        'ENDPOINT':'C:\NEO4J_HOME\data\datos_prueba'
    }
}  
# Hosts/domain names that are valid for this site; required if DEBUG is False
# See https://docs.djangoproject.com/en//ref/settings/#allowed-hosts
ALLOWED_HOSTS = [] 
# Local time zone for this installation. Choices can be found here:
# http://en.wikipedia.org/wiki/List_of_tz_zones_by_name
# although not all choices may be available on all operating systems.
# In a Windows environment this must be set to your system time zone.
TIME_ZONE = 'America/Chicago' 
# Language code for this installation. All choices can be found here:
# http://www.i18nguy.com/unicode/language-identifiers.html
LANGUAGE_CODE = 'en-us' 
SITE_ID = 1 
# If you set this to False, Django will make some optimizations so as not
# to load the internationalization machinery.
USE_I18N = True 
# If you set this to False, Django will not format dates, numbers and
# calendars according to the current locale.
USE_L10N = True 
# If you set this to False, Django will not use timezone-aware datetimes.
USE_TZ = True 
# Absolute filesystem path to the directory that will hold user-uploaded files.
# Example: "/home/media/media.lawrence.com/media/"
MEDIA_ROOT = '' 
# URL that handles the media served from MEDIA_ROOT. Make sure to use a
# trailing slash.
# Examples: "http://media.lawrence.com/media/", "http://example.com/media/"
MEDIA_URL = '' 
# Absolute path to the directory static files should be collected to.
# Don't put anything in this directory yourself; store your static files
# in apps' "static/" subdirectories and in STATICFILES_DIRS.
# Example: "/home/media/media.lawrence.com/static/"
STATIC_ROOT = '' 
# URL prefix for static files.
# Example: "http://media.lawrence.com/static/"
STATIC_URL = '/static/' 
# Additional locations of static files
STATICFILES_DIRS = (
    # Put strings here, like "/home/html/static" or "C:/www/django/static".
    # Always use forward slashes, even on Windows.
    # Don't forget to use absolute paths, not relative paths.
) 
# List of finder classes that know how to find static files in
# various locations.
STATICFILES_FINDERS = (
    'django.contrib.staticfiles.finders.FileSystemFind  er',
    'django.contrib.staticfiles.finders.AppDirectories  Finder',
#    'django.contrib.staticfiles.finders.DefaultStorage  Finder',
) 
# Make this unique, and don't share it with anybody.
SECRET_KEY = 'r*j4jyr1d#g0@@wa9e1kvix&-stadl!he&+!#@dcixgzd%sj5h' 
# List of callables that know how to import templates from various sources.
TEMPLATE_LOADERS = (
    'django.template.loaders.filesystem.Loader',
    'django.template.loaders.app_directories.Loader',
#     'django.template.loaders.eggs.Loader',
) 
MIDDLEWARE_CLASSES = (
    'django.middleware.common.CommonMiddleware',
    'django.contrib.sessions.middleware.SessionMiddlew  are',
    'django.middleware.csrf.CsrfViewMiddleware',
    'django.contrib.auth.middleware.AuthenticationMidd  leware',
    'django.contrib.messages.middleware.MessageMiddlew  are',
    # Uncomment the next line for simple clickjacking protection:
    # 'django.middleware.clickjacking.XFrameOptionsMiddl  eware',
) 
ROOT_URLCONF = 'neo_prueba2.urls' 
# Python dotted path to the WSGI application used by Django's runserver.
WSGI_APPLICATION = 'neo_prueba2.wsgi.application' 
TEMPLATE_DIRS = (
    # Put strings here, like "/home/html/django_templates" or "C:/www/django/templates".
    # Always use forward slashes, even on Windows.
    # Don't forget to use absolute paths, not relative paths.
) 
INSTALLED_APPS = (
    'django.contrib.auth',
    'django.contrib.contenttypes',
    'django.contrib.sessions',
    'django.contrib.sites',
    'django.contrib.messages',
    'django.contrib.staticfiles',
    # Uncomment the next line to enable the admin:
    'django.contrib.admin',
    # Uncomment the next line to enable admin documentation:
    'django.contrib.admindocs',
) 
# A sample logging configuration. The only tangible logging
# performed by this configuration is to send an email to
# the site admins on every HTTP 500 error when DEBUG=False.
# See http://docs.djangoproject.com/en/dev/topics/logging for
# more details on how to customize your logging configuration.
LOGGING = {
    'version': 1,
    'disable_existing_loggers': False,
    'filters': {
        'require_debug_false': {
            '()': 'django.utils.log.RequireDebugFalse'
        }
    },
    'handlers': {
        'mail_admins': {
            'level': 'ERROR',
            'filters': ['require_debug_false'],
            'class': 'django.utils.log.AdminEmailHandler'
        }
    },
    'loggers': {
        'django.request': {
            'handlers': ['mail_admins'],
            'level': 'ERROR',
            'propagate': True,
        },
    }
}