Si vas a trabajar en entorno microsoft te aconsejo Microsoft SQL Server
Cita: http://www.microsoft.com/sql/prodinf.../prodinfo.mspx
MSDE 2000 Product Information
Important Note: Microsoft SQL Server Desktop Engine (MSDE)
will not be supported on the Microsoft Vista operating system. If you plan to build an application and redistribute a database with it, you should consider using
SQL Server 2005 Express Edition instead. For more information, see the Running SQL Server on Windows Vista page on microsoft.com.